Intron Retention via Alternative Splicing as a Signature of Aging

In recent years researchers have investigated changes in alternative splicing in the context of aging and age-related disease. It is thought to be important in cellular senescence, for example, but that is just one line item in the bigger picture. A given gene can code for multiple different proteins, and alternative splicing is the name given to the processes by which those different proteins are produced. A gene contains discrete DNA sequences called exons and introns, the former passed into the protein production process, and the latter removed during RNA splicing. The canonical protein produced from this genetic blueprint contains all of the exons, joined in sequence, but alternative splicing may drop exons, resulting in a different protein. The balance between the proteins produced from a

From https://www.fightaging.org/archives/2019/03/intron-retention-via-alternative-splicing-as-a-signature-of-aging/

from
https://healthnews010.wordpress.com/2019/03/22/intron-retention-via-alternative-splicing-as-a-signature-of-aging/

from https://karlfletcher.blogspot.com/2019/03/intron-retention-via-alternative.html

from
https://karlfletcher1.tumblr.com/post/183623581413