Low Mitochondrial Permeability is Required for Autophagy to Extend Life Span

Mitochondria are the power plants of the cell, generating the chemical energy store molecule adenosine triphosphate (ATP) that powers cellular processes. Every cell possesses a herd of mitochondria, replicating like bacteria, and monitored by quality control mechanisms. Damaged, potentially harmful mitochondria are removed and dismantled for raw materials through a variant of autophagy called mitophagy. A mountain of evidence links mitochondrial function to aging, just as a mountain of evidence links the cellular recycling mechanisms of autophagy to aging. Both mitochondrial function and autophagic activity decline with age, producing downstream consequences that contribute to age-related diseases. There is the strong suspicion, with evidence to back it up, that it is the quality control of mitochondria, and thus maintenance of mitochondrial function without harmful side-effects resulting

From https://www.fightaging.org/archives/2019/04/low-mitochondrial-permeability-is-required-for-autophagy-to-extend-life-span/

from
https://healthnews010.wordpress.com/2019/04/06/low-mitochondrial-permeability-is-required-for-autophagy-to-extend-life-span/

from https://karlfletcher.blogspot.com/2019/04/low-mitochondrial-permeability-is.html

from
https://karlfletcher1.tumblr.com/post/183979519983